Groundery

We’re at the Dawn of the Ozempic Era — and It’s Really Weird

Audio

177 claims analyzed

Shared session

Claims177

Ezra Klein
Ezra Klein
·Partial4/10

A Kaiser Family Foundation poll found that one in eight Americans is currently taking a GLP-1 drug.

Julia Belluz
Julia Belluz
·Partial4/10

France has used land-use planning since the late 1800s to minimize grocery-store size.

Julia Belluz
Julia Belluz
·Partial6/10

Childhood diabetes is caused by the food environment.

Julia Belluz
Julia Belluz
·Supported7/10

GLP-1 drugs rival bariatric surgery as a medical intervention for weight loss.

Julia Belluz
Julia Belluz
·Supported7/10

GLP-1 drugs are synthetic versions of a hormone the body produces naturally.

Julia Belluz
Julia Belluz
·Supported7/10

People have to stay on GLP-1 drugs to keep the weight-loss benefits.

Ezra Klein
Ezra Klein
·Supported7/10

People with diabetes have to keep taking insulin.

Julia Belluz
Julia Belluz
·Supported7/10

Statins reduce cardiovascular risk by about 29%.

Julia Belluz
Julia Belluz
·Supported7/10

The sleep-apnea benefit of GLP-1 drugs depends on weight loss.

Julia Belluz
Julia Belluz
·Supported7/10

Dan Drucker helped discover the GLP-1 drug class.

Ezra Klein
Ezra Klein
·Supported7/10

In a Times survey, 63% of GLP-1 users said they would want to stay on the drug even if it did not work for weight loss.

Julia Belluz
Julia Belluz
·Supported7/10

Long-term data are lacking for tirzepatide.

Julia Belluz
Julia Belluz
·Supported7/10

Most Americans do not get enough sleep.

Julia Belluz
Julia Belluz
·Supported7/10

A compound used in explosives manufacturing after World War I caused people to lose weight.

Ezra Klein
Ezra Klein
·Supported7/10

The New Yorker tested peptides sold online and found that many contained lead.

Ezra Klein
Ezra Klein
·Supported7/10

The New Yorker tested peptides sold online and found that many were not at the right dose.

Julia Belluz
Julia Belluz
·Supported7/10

Television ads with famous actors opposed increased FDA regulation of dietary supplements.

Julia Belluz
Julia Belluz
·Supported7/10

California is considering reducing ultra-processed foods in school lunches.

Julia Belluz
Julia Belluz
·Supported7/10

West Virginia is considering reducing ultra-processed foods in school lunches.

Ezra Klein
Ezra Klein
·Supported8/10

GLP-1 drugs affect addiction.

Julia Belluz
Julia Belluz
·Supported8/10

GLP-1 weight-loss drugs do not increase energy burn.

Julia Belluz
Julia Belluz
·Supported8/10

Hungry rodents are more likely to exhibit addictive behaviors.

Ezra Klein
Ezra Klein
·Supported8/10

The New Yorker tested peptides sold online and found that many contained impurities.

Julia Belluz
Julia Belluz
·Supported8/10

Representatives from states with large supplement manufacturers pushed for a lax regulatory environment for dietary supplements.

Julia Belluz
Julia Belluz
·Supported8/10

Childhood fatty liver disease is caused by the food environment.

Julia Belluz
Julia Belluz
·Supported8/10

France has fresh food markets in every district.

Julia Belluz
Julia Belluz
·Supported8/10

Food producers in the United States once used brick dust to dye food.

Ezra Klein
Ezra Klein
·Supported9/10

GLP-1 drugs protect kidney health.

Ezra Klein
Ezra Klein
·Supported9/10

GLP-1 drugs are protective of kidneys.

Ezra Klein
Ezra Klein
·Supported9/10

GLP-1 drugs are protective of livers.

Ezra Klein
Ezra Klein
·Supported9/10

GLP-1 drugs protect liver health.

Julia Belluz
Julia Belluz
·Supported9/10

The United States has a relatively unrestricted approach to pharmaceutical marketing.

Julia Belluz
Julia Belluz
·Supported9/10

The telemedicine industry has flourished since COVID.

Julia Belluz
Julia Belluz
·Supported9/10

GLP-1 is produced to a lesser extent in the pancreas.

Julia Belluz
Julia Belluz
·Supported9/10

Some GLP-1 weight-loss drugs produce about 15 percent weight loss.

Julia Belluz
Julia Belluz
·Supported9/10

Stimulating the brain GLP-1 system is necessary to get the weight-loss effects of GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported9/10

GLP-1 drugs have to reach the brain to affect appetite.

Julia Belluz
Julia Belluz
·Supported9/10

One theory is that GLP-1 drugs activate a brain area that signals toxins in circulation.

Julia Belluz
Julia Belluz
·Supported9/10

Activation of that brain region shuts down appetite.

Julia Belluz
Julia Belluz
·Supported9/10

Almost all genetic variants associated with common obesity act in the brain.

Julia Belluz
Julia Belluz
·Supported9/10

The genetic variants associated with common obesity almost all act in the brain.

Julia Belluz
Julia Belluz
·Supported9/10

Sleep deprivation makes people eat more.

Julia Belluz
Julia Belluz
·Supported9/10

Vomiting is one of the most common known side effects of GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported9/10

Diarrhea is one of the most common known side effects of GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported9/10

There is no screening yet for eating disorders in young people before prescribing GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported9/10

There is no screening for eating disorders in young people receiving GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported9/10

People with obesity face a pay penalty.

Julia Belluz
Julia Belluz
·Supported9/10

About 1% of children eligible for GLP-1 obesity medications are currently taking GLP-1 drugs.

Ezra Klein
Ezra Klein
·Supported9/10

A study found large drops in mortality from cardiac events among GLP-1 drug users.

Ezra Klein
Ezra Klein
·Supported9/10

The cardiac mortality drops seen in a GLP-1 drug study did not appear to depend on weight loss.

Julia Belluz
Julia Belluz
·Supported9/10

More benefits researchers are discovering from GLP-1 drugs appear to be independent of weight loss.

Julia Belluz
Julia Belluz
·Supported9/10

Some people obtain GLP-1-related research chemicals through TikTok influencers.

Ezra Klein
Ezra Klein
·Supported9/10

Some people taking GLP-1 drugs report anhedonia.

Julia Belluz
Julia Belluz
·Supported9/10

Clinical trials of GLP-1 drugs for addictive behaviors have had mixed results.

Julia Belluz
Julia Belluz
·Supported9/10

Doctors at Stanford turned an explosives-manufacturing ingredient into a weight-loss drug.

Ezra Klein
Ezra Klein
·Supported9/10

Michael Bloomberg wanted to tax sodas in New York.

Julia Belluz
Julia Belluz
·Supported9/10

West Virginia is considering banning certain food additives.

Julia Belluz
Julia Belluz
·Supported9/10

California is considering banning certain food additives.

Ezra Klein
Ezra Klein
·Supported10/10

GLP-1 drugs appear to protect heart health independent of weight loss.

Ezra Klein
Ezra Klein
·Supported10/10

GLP-1 drugs protect heart health independently of weight loss.

Ezra Klein
Ezra Klein
·Supported10/10

Research is ongoing into GLP-1 drugs for Alzheimer's disease.

Ezra Klein
Ezra Klein
·Supported10/10

There is ongoing research on GLP-1 drugs and dementia.

Ezra Klein
Ezra Klein
·Supported10/10

There is ongoing research on GLP-1 drugs and Alzheimer's disease.

Ezra Klein
Ezra Klein
·Supported10/10

Research is ongoing into GLP-1 drugs for dementia.

Ezra Klein
Ezra Klein
·Supported10/10

GLP-1 drugs were originally approved for diabetes.

Ezra Klein
Ezra Klein
·Supported10/10

Diabetes can cause limb amputation.

Ezra Klein
Ezra Klein
·Supported10/10

Diabetes can cause blindness.

Julia Belluz
Julia Belluz
·Supported10/10

The human body naturally produces GLP-1.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 is produced in the gut.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 is produced in the brain.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 drugs stimulate the pancreas to release insulin only when blood sugar is high.

Julia Belluz
Julia Belluz
·Supported10/10

Insulin therapy can put patients at risk of very low blood sugar levels.

Julia Belluz
Julia Belluz
·Supported10/10

Taking insulin can put patients at risk of very low blood sugar levels.

Ezra Klein
Ezra Klein
·Supported10/10

Tirzepatide has more mechanisms of action than Wegovy.

Ezra Klein
Ezra Klein
·Supported10/10

Tirzepatide is marketed under the name Zepbound.

Julia Belluz
Julia Belluz
·Supported10/10

People taking GLP-1 drugs lose about 15 percent of body weight depending on the drug.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 drugs produce weight loss by reducing appetite.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 drugs do not produce weight loss by increasing energy burn.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 is released after eating.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 helps signal satiety.

Julia Belluz
Julia Belluz
·Supported10/10

Activation of that brain region increases nausea.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 acts as a neurotransmitter in the brain.

Julia Belluz
Julia Belluz
·Supported10/10

Most people with obesity have common obesity.

Julia Belluz
Julia Belluz
·Supported10/10

Common obesity arises from more than 1,000 genetic variants.

Julia Belluz
Julia Belluz
·Supported10/10

Not sleeping enough makes people eat more.

Julia Belluz
Julia Belluz
·Supported10/10

For people who lose weight effectively on GLP-1 drugs, cravings can change.

Julia Belluz
Julia Belluz
·Supported10/10

Many GLP-1 users report that food noise disappears.

Julia Belluz
Julia Belluz
·Supported10/10

Some people are sensitive to GLP-1 drugs while others are insensitive.

Ezra Klein
Ezra Klein
·Supported10/10

In studies, people often do not stay on GLP-1 drugs for long.

Ezra Klein
Ezra Klein
·Supported10/10

Some people stop taking GLP-1 drugs because of cost.

Julia Belluz
Julia Belluz
·Supported10/10

Nausea is one of the most common side effects of GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported10/10

Some lawsuits over GLP-1 drugs concern severe stomach problems.

Julia Belluz
Julia Belluz
·Supported10/10

Lawsuits allege that GLP-1 drugs can cause severe stomach problems.

Julia Belluz
Julia Belluz
·Supported10/10

Some lawsuits over GLP-1 drugs concern ocular nerve damage.

Julia Belluz
Julia Belluz
·Supported10/10

Lawsuits allege that GLP-1 drugs can cause damage to the ocular nerve.

Julia Belluz
Julia Belluz
·Supported10/10

The GLP-1 lawsuits allege that people were not properly warned about potential side effects.

Julia Belluz
Julia Belluz
·Supported10/10

People tend to regain weight after stopping GLP-1 drugs.

Julia Belluz
Julia Belluz
·Supported10/10

The appetite-suppressing effect of GLP-1 drugs disappears after stopping the drugs.

Ezra Klein
Ezra Klein
·Supported10/10

The therapeutic effect of statins goes away when patients stop taking statins.

Julia Belluz
Julia Belluz
·Supported10/10

Pediatricians prescribe GLP-1 drugs to children.

Julia Belluz
Julia Belluz
·Supported10/10

People with obesity face discrimination.

Julia Belluz
Julia Belluz
·Supported10/10

People with obesity face stigma.

Julia Belluz
Julia Belluz
·Supported10/10

At the population level, higher BMI is associated with higher health risks.

Julia Belluz
Julia Belluz
·Supported10/10

Ozempic came onto the market as a diabetes treatment.

Julia Belluz
Julia Belluz
·Supported10/10

Participants in diabetes trials of GLP-1 drugs started losing weight as doses increased.

Julia Belluz
Julia Belluz
·Supported10/10

Companies are required to examine cardiovascular-event risks for new diabetes drugs.

Ezra Klein
Ezra Klein
·Supported10/10

Fen-Phen increased the risk of cardiovascular events.

Julia Belluz
Julia Belluz
·Supported10/10

A cardiovascular outcomes trial of a GLP-1 drug found a 20% reduction in cardiovascular risk.

Ezra Klein
Ezra Klein
·Supported10/10

Observational studies show that people taking GLP-1 drugs have much lower dementia risk.

Ezra Klein
Ezra Klein
·Supported10/10

A randomized controlled trial found that GLP-1 drugs did not improve outcomes for people with Alzheimer's disease.

Julia Belluz
Julia Belluz
·Supported10/10

A GLP-1-related drug is approved to treat sleep apnea.

Julia Belluz
Julia Belluz
·Supported10/10

GLP-1 drugs appear to lower inflammation.

Julia Belluz
Julia Belluz
·Supported10/10

Mice and cell research has suggested that GLP-1 drugs could benefit post-concussion syndrome.

Julia Belluz
Julia Belluz
·Supported10/10

No randomized controlled trial has tested GLP-1 drugs for post-concussion syndrome.

Julia Belluz
Julia Belluz
·Supported10/10

Some people obtain GLP-1 drugs through low-barrier telemedicine prescriptions.

Julia Belluz
Julia Belluz
·Supported10/10

Oral forms of GLP-1 drugs are now available.

Julia Belluz
Julia Belluz
·Supported10/10

Some GLP-1 drugs are going generic.

Ezra Klein
Ezra Klein
·Supported10/10

Retatrutide is an Eli Lilly drug.

Ezra Klein
Ezra Klein
·Supported10/10

Eli Lilly makes Zepbound.

Ezra Klein
Ezra Klein
·Supported10/10

Retatrutide is in clinical trials.

Julia Belluz
Julia Belluz
·Supported10/10

Retatrutide is a research compound still under study.

Julia Belluz
Julia Belluz
·Supported10/10

Retatrutide targets three hormone receptors.

Julia Belluz
Julia Belluz
·Supported10/10

Semaglutide targets one hormone receptor.

Julia Belluz
Julia Belluz
·Supported10/10

Tirzepatide targets more than just the GLP-1 receptor.

Julia Belluz
Julia Belluz
·Supported10/10

Long-term data are lacking for retatrutide.

Julia Belluz
Julia Belluz
·Supported10/10

Retatrutide causes faster and more dramatic weight loss in research so far.

Ezra Klein
Ezra Klein
·Supported10/10

Retatrutide appears to increase energy use.

Julia Belluz
Julia Belluz
·Supported10/10

FDA approval of retatrutide requires randomized controlled trials.

Julia Belluz
Julia Belluz
·Supported10/10

Some people are buying retatrutide from illicit sources before FDA approval.

Julia Belluz
Julia Belluz
·Supported10/10

Most Americans do not meet the minimum daily recommended intake of fruits and vegetables.

Julia Belluz
Julia Belluz
·Supported10/10

Most Americans do not get enough physical activity.

Speaker 3
·Supported10/10

India is the biggest adopter of cryptocurrency globally.

Speaker 3
·Supported10/10

Estonia offers online voting in all of its elections.

Julia Belluz
Julia Belluz
·Supported10/10

A compound used in explosives manufacturing after World War I sped up metabolism.

Julia Belluz
Julia Belluz
·Supported10/10

An explosives-derived weight-loss drug was taken by hundreds of thousands of people.

Julia Belluz
Julia Belluz
·Supported10/10

An explosives-derived weight-loss drug became one of the FDA's first targets.

Julia Belluz
Julia Belluz
·Supported10/10

An explosives-derived weight-loss drug killed people through side effects.

Julia Belluz
Julia Belluz
·Supported10/10

An explosives-derived weight-loss drug caused eye problems.

Julia Belluz
Julia Belluz
·Supported10/10

Supplement makers helped mount a major campaign against stricter FDA regulation of dietary supplements.

Julia Belluz
Julia Belluz
·Supported10/10

A public letter-writing campaign opposed increased FDA regulation of dietary supplements.

Ezra Klein
Ezra Klein
·Supported10/10

Fen-Phen was a once-popular diet drug that later proved harmful.

Ezra Klein
Ezra Klein
·Supported10/10

Coca-Cola used to contain cocaine.

Julia Belluz
Julia Belluz
·Supported10/10

The long-term effects of GLP-1 drugs in young people are not understood.

Julia Belluz
Julia Belluz
·Supported10/10

The number of children with diabetes is increasing.

Julia Belluz
Julia Belluz
·Supported10/10

The number of children with fatty liver disease is increasing.

Ezra Klein
Ezra Klein
·Supported10/10

Robert F. Kennedy Jr. is the secretary of Health and Human Services.

Julia Belluz
Julia Belluz
·Supported10/10

France uses school lunches as a policy lever to feed children healthfully.

Julia Belluz
Julia Belluz
·Supported10/10

The United States began protecting people against acute food poisoning more than 100 years ago.

Julia Belluz
Julia Belluz
·Supported10/10

Food producers in the United States once put calf brains in milk.

Julia Belluz
Julia Belluz
·Supported10/10

Food producers in the United States once put lead in food.

Julia Belluz
Julia Belluz
·Supported10/10

The FDA originated from U.S. efforts to protect consumers from adulterated food.

Julia Belluz
Julia Belluz
·Supported10/10

The USDA meat inspection program came after the publication of Upton Sinclair's book.

Julia Belluz
Julia Belluz
·Supported10/10

Programs that made local and fresh produce available for school lunches have been cut.

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Transcript